Another tragic but educational sepsis case

Tue Jul 8 17:14:11 UTC 2014

Hi Jason,

Thank you for bringing this unfortunate patient to our attention. He is similar in many ways  to a 13 or 14 year old boy who died from severe sepsis in similar circumstances in New York city about 2 or 3 years back. The most striking thing about him, as in your patient, was how his proper care was neglected till it was too late. The main reason for these two deaths and several others we know of is knowledge deficit among physicians in general about severe sepsis and its lethal nature if it is not recognized and treated in a timely manner. Indeed, this disorder should be placed in the same category as acute myocardial infarction and stroke as a time sensitive disease. After the tremendous publicity due to NY patient's death, the Commissioner of Health in Née City made it mandatory for all physicians in the city to take a course about severe sepsis.
Briefly, the important facts about severe sepsis are as follows:

1.It is a major cause of death, killing about 240,000 patients, as many as acute myocardial infarction, each year in United States.
2.It is a complication of infection, characterized by generalized micro vascular inflammation.
3.It is a progressive disorder characterized by worsening hypotension, tissue hypo perfusion with time and ending in multiorgan failure and death if not recognised and treated early.
4.Unfortunately, early clinical features of severe sepsis are subtle or absent and therefore it is not often suspected in its early stage. But altered mental status in a patient with infections a very important sign and should always make us suspect severe sepsis.
5.The important early features of severe sepsis are (a) low or borderline blood pressure in a patient with infection and/or (b) elevated lactic acid indicating tissue hypo perfusion in a patient with infection.
6. In our ER, blood pressure is taken carefully and frequently and lactic acid is determined in every patient with infection so that severe sepsis can be identified early.
7. The treatment of severe sepsis, once it is recognised is simple and consists of:
(a) Rapid, large volume fluid infusion
(b)Prompt administration of appropriate antibiotics
(c) Careful monitoring usually in ICU.

I believe education and increased awareness  about lethal nature of severe sepsis may be the key to early recognition and treatment of this deadly disease.

All the best


Bimal Jain MD
NorthShore Medical Center
Lynn, MA 01904

From: Vic Nicholls [mailto:nichollsvi2 at GMAIL.COM]
Sent: Monday, July 07, 2014 2:05 PM
Subject: Re: [IMPROVEDX] Another tragic but educational sepsis case

One item to this: even if you come with medical research, and you are confident in your opinions, doctors frequently don't accept it. Its not just me but several others also.

On 7/7/2014 1:10 PM, Jason Maude wrote:
The Health Service Ombudsman in the UK recently published a report on the tragic case of Sam Morrish, a 3 year old boy who died from sepsis. He had had flu but the various clinicians he saw failed to recognise the secondary infection until it was too late. Sam Morrish came in contact with several clinicians from his primary care practice, NHS Direct (telephone triage service) and emergency clinicians at his local hospital.

These reports are a fantastic educational resource as they are incredibly detailed containing in depth accounts from all the parties concerned and applicable to many diseases. You can access the report from this link:

On reading the report, I was struck by how the mother's sentiments were very accurate but she relied on her local GPs and the national phone triage service to tell her what to do rather than directly going to the Emergency Department which may have acted more appropriately.

I wondered whether a patient triage tool attached to a symptom checker could help patients in this situation have more confidence in their own convictions rather than wait to be told what to do. If anybody does have any feedback on our new triage tool (listserv message of June 27th), I would really appreciate it.

Many thanks

Jason Maude
Founder and CEO Isabel Healthcare
Tel: +44 1428 644886
Tel: +1 703 879 1890<>




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